Community Request Diacetyl Center for Research on Ingredient Safety Research indicates that certain flavoring chemicals used in e cigarettes can irritate lung tissue and trigger inflammatory responses in laboratory settings. Some compounds, such as diacetyl, have been linked to respiratory damage when , The notion that vaping causes "popcorn lungs" due to diacetyl in e liquids is based on outdated information. , ., While diacetyl was once used as a flavoring agent in some e liquids and linked to In Cigarettes Or Did You Know Some Flavored Vapes Contain Diacetyl, A Bronchiolitis Obliterans Vaping